. Keep away from reach of

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Amlodipine medication is a calcium channel blocker Corey Clement Eagles Jersey , prescribed for high blood pressure and chest pain. It widens blood vessels and improves blood flow by not making the heart pump harder.

Mechanism of action:

Amlodipine decreases arterial smooth muscle contractility and subsequent vasoconstriction by inhibiting the influx of calcium ions through L-type calcium channels. Calcium ions entering the cell through these channels bind to calmodulin. Calcium-bound calmodulin then binds to and activates myosin light chain kinase (MLCK). Activated MLCK catalyzes the phosphorylation of the regulatory light chain subunit of myosin, a key step in muscle contraction. Signal amplification is achieved by calcium-induced calcium release from the sarcoplasmic reticulum through ryanodine receptors. Inhibition of the initial influx of calcium decreases the contractile activity of arterial smooth muscle cells and results in vasodilation. The vasodilatory effects of amlodipine result in an overall decrease in blood pressure. Amlodipine is a long-acting CCB that may be used to treat mild to moderate essential hypertension and exertion-related angina (chronic stable angina). Another possible mechanism is that amlodipine inhibits vascular

smooth muscle carbonic anhydrase I activity causing cellular pH increases which may be involved in regulating intracelluar calcium influx through calcium channels.

Dosage & When it is to be taken:

Adults- PO- The usual initial dose is 5 mg once daily with a maximum dose of 10 mg once daily.

Children- 6 to 17 years- The effective dose is 2.5 mg to 5 mg once daily.

Warnings and Precautions:
Caution should be exercised in patients with history of heart failure or liver disease, any allergy, who are taking other medications, elderly, during pregnancy and breastfeeding.

It may cause drowsiness or dizziness, do not drive a car or operate machinery while taking this medication.

Avoid alcohol consumption.

It should not be used in children less than 6 years old.

Side Effects:

Most Common - Dizziness, palpitations, flushing and fluid retention.

Heart - Abnormal heart rhythm, slow heart rate, chest pain, low blood pressure, poor blood circulation, fainting, fast heart rate and inflammation of blood vessels.

Central Nervous System - Sensory loss, nerve disease, tingling, tremor, unsteadiness, sexual dysfunction (male1 and female), sleepless, nervousness, depression, abnormal dreams, anxiety and depersonalization.

Gastrointestinal - Loss of appetite, constipation, indigestion, difficulty in swallowing, diarrhea, flatulence, inflammation of pancreas, vomiting and gum swelling.

General - Allergic reactions, shock, weakness, back pain, hot flushes, uneasiness, pain, rigors, increased sweating, weight gain and weight loss.

Musculoskeletal - Joint pain, muscle cramps and muscle pain.

Respiratory - Difficulty in breathing and nose bleed.

Skin - Redness of the skin, itching, increased sweating and rash.

Eye and ENT - Abnormal vision, eye inflammation, blurreddouble vision, eye pain and ringing in the ear.

Genitourinary - Urinary frequency and night time urination.

Metabolic - Dry mouth, increased sugar level and thirst.

Blood - Bruising, decrease in white blood cells and platelets.

Storage Conditions:

Store it at room temperature and in an airtight container. Protect from heat, light and moisture. Keep away from reach of children.

Knowing the order of events for your marriage day can help abate the nerves of the couple. It additionally can help in the planning of the big day. From the processional to the vows to the recessional, the wedding ceremony is a beautiful day the guests and the wedding party will cherish for always.

The processional is the start of the wedding. This is the decisive part that involves the reception of the bridal party and the bride, and is more often than not set to music. Once the wedding party is in set, its time for the greeting. The greeting is performed by the minister or officiant to gladly received the guests to the ceremony.

It can also be a simple thank you to the guests or a reading of how the couple met. The statement of intention is when all who attend the wedding are told the couple intend to be married. The priest may also elect to talk in brief about the vow of being wed at this time.

The exchange of marriage vows is the lovingly binding part of the ceremony. This is when the couple make vows toeach other. The couple may also wish to read out loud their own vows at this time. Following the vows, the couple will exchange wedding rings. The bride and groom take turns placing the ring on the finger of one another, with pledge pronounced to legally
seal the union.

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